La Chiesa cattolica romana ha dominato a lungo la vita spirituale e politica del Paraguay. Sebbene si opponga mirabilmente alla corruzione e all'immoralità, c'è anche molto tradizionalismo superstizioso, forte devozione a Maria e schiavitù legata all'occulto a molte divinità e usanze precristiane. Queste pratiche impediscono a milioni di persone di essere libere nel Signore Gesù e devono essere interrotte dalla preghiera. La Chiesa spesso si oppone attivamente all'opera degli evangelici. Il Paraguay non ha mai avuto un vero risveglio spirituale, e pochi della maggioranza cattolica ispano-guaranì hanno un rapporto vivo con Cristo.
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