Biserica romano-catolică a dominat de multă vreme viața spirituală și politică din Paraguay. Deși se opune în mod admirabil corupției și imoralității, există și mult tradiționalism superstițios, devotament puternic față de Maria și sclavie legată de ocultism față de multe zeități și obiceiuri precreștine. Aceste practici feresc milioane de oameni de libertate în Domnul Isus și trebuie să fie rupte prin rugăciune. Biserica se opune adesea activ lucrării evanghelicilor. Paraguay nu a avut niciodată o adevărată trezire spirituală și puțini dintre majoritatea catolică spaniolă-guaraní au o relație vie cu Hristos.
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